Semi-quantitative Procalcitonin Test for the Diagnosis of Bacterial Infection: Clinical Use and Experience in Japan

Autor: Hideto Oshita, Masakazu Kamitsuna, Joji Sakurai
Jazyk: angličtina
Předmět:
Adult
Calcitonin
Male
Microbiology (medical)
medicine.medical_specialty
Adolescent
inflammation marker
Calcitonin Gene-Related Peptide
Sensitivity and Specificity
Procalcitonin
C-reactive protein
Leukocyte Count
Internal medicine
Immunology and Microbiology(all)
medicine
Humans
Immunology and Allergy
Protein Precursors
white blood cell counts
Aged
Retrospective Studies
Aged
80 and over
General Immunology and Microbiology
Receiver operating characteristic
biology
business.industry
Retrospective cohort study
Bacterial Infections
General Medicine
Middle Aged
medicine.disease
Systemic Inflammatory Response Syndrome
Surgery
Systemic inflammatory response syndrome
Clinical Practice
Infectious Diseases
ROC Curve
Clinical diagnosis
biology.protein
Female
diagnostic accuracy
business
Semi quantitative
procalcitonin
Zdroj: Journal of Microbiology, Immunology and Infection. (3):222-227
ISSN: 1684-1182
DOI: 10.1016/S1684-1182(10)60035-7
Popis: Background/PurposeThe efficacy of the rapid semi-quantitative procalcitonin (PCT) test for the diagnosis of bacterial infection was evaluated in patients with systemic inflammatory response syndrome.MethodsA retrospective observational study was performed from June to December 2008 at the Chugoku Rosai General Hospital, Japan. This study analyzed consecutive patients (both outpatients and inpatients) who developed systemic inflammatory response syndrome and whose PCT test was measured semi-quantitatively within 24 hours of onset, or at the first hospital visit. Based on the clinical diagnosis, the patients were divided into two groups. Group I comprised patients with a bacterial infection, and group II comprised patients with a non-bacterial infection, or non-infectious disease. Receiver operating characteristic curves were used to evaluate the diagnostic value of the semi-quantitative PCT test kit, C-reactive protein levels and white blood cells counts for the detection of bacterial infections, and the areas under the resulting curves were compared.ResultsA total of 168 patients were included and divided into groups I (n=112) and II (n=56). Group I showed a significantly higher percentage of positive PCT tests (≥ 0.5 ng/mL) than group II (67.8% vs. 19.6%, p < 0.001). PCT showed a sensitivity of 67.8% [95% confidence interval (CI)=58.4–76.4] and a specificity of 80.4% (95% CI=67.6–89.8). The areas under the resulting curves for PCT (0.764) were significantly larger than those seen for C-reactive protein (0.650, p=0.02) and white blood cells (0.618, p=0.006).ConclusionThe semi-quantitative PCT test is as useful for distinguishing bacterial infection from other inflammatory diseases in common clinical practice as the quantitative PCT.
Databáze: OpenAIRE
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