Opioid Receptors Gene Polymorphism and Heroin Dependence in Iran
| Autor: | Niloufar Ashtari, Mehdi Mehdizadeh, Ronak Shabani, Sara Soleimani Asl, Hugo Bergen, Amir Roointan, Shayan Amiri, Parastoo Mardani |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty media_common.quotation_subject Single-nucleotide polymorphism Heroin lcsh:RC321-571 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Internal medicine mental disorders medicine Receptor κ-opioid receptor lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry media_common δ-opioid receptor Substance dependence Addiction medicine.disease Genotype frequency Single nucleotide polymorphism 030104 developmental biology Endocrinology Opioid μ-opioid receptor Neurology (clinical) Gene polymorphism 030217 neurology & neurosurgery Research Paper medicine.drug |
| Zdroj: | Basic and Clinical Neuroscience, Vol 9, Iss 2, Pp 101-106 (2018) Scopus-Elsevier Basic and Clinical Neuroscience |
| ISSN: | 2228-7442 |
| Popis: | Introduction: Genes often have multiple polymorphisms that interact with each other and the environment in different individuals. Variability in the opioid receptors can influence opiate withdrawal and dependence. In humans, A118G Single Nucleotide Polymorphisms (SNP) on μ-Opioid Receptor (MOR), 36 G>T in κ-Opioid Receptor (KOR), and T921C in the δ-Opioid Receptor (DOR) have been found to associate with substance dependence. Methods: To investigate the association between opioid receptors gene polymorphism and heroin addiction, 100 control subjects with no history of opioid use, and 100 heroin addicts (50% males and 50% females) in Tehran (capital of Iran), were evaluated. A118G, 36 G>T, and T921C SNPs on the MOR, KOR, DOR genes, respectively, were genotyped by sequencing. Results: We found no differences in either allele or genotype frequency for MOR, KOR and DOR genes SNPs between controls and subjects addicted to heroin. Conclusion: The relationships among polymorphisms may be important in determining the risk profile for complex diseases such as addiction, but opioid addiction is a multifactorial syndrome which is partially hereditary and partially affected by the environment. |
| Databáze: | OpenAIRE |
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