Photodynamic Therapy with Methyl-aminolaevulinic Acid for Mycosis Fungoides
| Autor: | Kee Suck Suh, Jae Woo Baek, Sang Tae Kim, Jin Seuk Kang, Dong Young Kang, Young Seung Jeon |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Skin Neoplasms medicine.medical_treatment Photodynamic therapy Occlusive Dressings Dermatology Lesion Mycosis Fungoides Republic of Korea Biopsy medicine Humans Complete response Aged Mycosis fungoides Photosensitizing Agents medicine.diagnostic_test business.industry Aminolaevulinic acid Aminolevulinic Acid General Medicine Middle Aged medicine.disease Lymphoma Occlusive dressing Photochemotherapy Female medicine.symptom business |
| Zdroj: | Acta Dermato Venereologica. 92:264-268 |
| ISSN: | 0001-5555 |
| DOI: | 10.2340/00015555-1261 |
| Popis: | Mycosis fungoides is the most common type of cutaneous T-cell lymphoma. There are a wide range of treatments for early-stage and advanced-stage mycosis fungoides. Photodynamic therapy (PDT) has emerged as a new treatment modality due to its safety and efficacy. The aim of this study was to investigate the safety and efficacy of PDT with methyl-aminolaevulinic acid (MAL) for the treatment of mycosis fungoides. Ten patients with mycosis fungoides were enrolled in this study. A 16.8% MAL cream was applied under occlusive dressing for 3 h. The lesion was irradiated at 37.5 J/cm2 with red light. The patients underwent two sessions of PDT at one-week intervals. Follow-up biopsy was performed 3 months after the last treatment. In case of partial response, treatment was repeated once a week until complete response. Seven patients had a good therapeutic response. Complete and partial responses were seen in 5 and 2 patients, respectively. During the follow-up period (8-31 months), 6 of the 7 patients remained in stable remission. The treatment was well-tolerated overall, and no patients discontinued the PDT due to pain. In conclusion, PDT with MAL is a fast, effective and well-tolerated treatment for unilesional mycosis fungoides. |
| Databáze: | OpenAIRE |
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