Critical Review on the Chemical Aspects of Cannabidiol (CBD) and Harmonization of Computational Bioactivity Data
| Autor: | Sara Anna Bonini, Alessandra Gianoncelli, Alberto Ongaro, Giovanni Ribaudo, Andrea Mastinu, Maurizio Memo |
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| Rok vydání: | 2020 |
| Předmět: |
Computer science
Harmonization Cannabis sativa Synthesis of CBD Biochemistry cannabidiol Drug Discovery medicine Humans Extractive methods Pharmaceutical industry Pharmacology Flexibility (engineering) Chromatography Molecular interactions business.industry Natural compound Organic Chemistry in silico studies Molecular Medicine Biochemical engineering business Cannabidiol medicine.drug |
| Zdroj: | Current Medicinal Chemistry. 28:213-237 |
| ISSN: | 0929-8673 |
| DOI: | 10.2174/0929867327666200210144847 |
| Popis: | Cannabidiol (CBD) is a non-psychotropic phytocannabinoid which represents one of the constituents of the “phytocomplex” of Cannabis sativa. This natural compound is attracting growing interest since when CBD-based remedies and commercial products were marketed. This review aims to exhaustively address the extractive and analytical approaches that have been developed for the isolation and quantification of CBD. Recent updates on cutting-edge technologies were critically examined in terms of yield, sensitivity, flexibility and performances in general, and are reviewed alongside original representative results. As an add-on to currently available contributions in the literature, the evolution of the novel, efficient synthetic approaches for the preparation of CBD, a procedure which is appealing for the pharmaceutical industry, is also discussed. Moreover, with the increasing interest on the therapeutic potential of CBD and the limited understanding of the undergoing biochemical pathways, the reader will be updated about recent in silico studies on the molecular interactions of CBD towards several different targets attempting to fill this gap. Computational data retrieved from the literature have been integrated with novel in silico experiments, critically discussed to provide a comprehensive and updated overview on the undebatable potential of CBD and its therapeutic profile. |
| Databáze: | OpenAIRE |
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