Connective Tissue Growth Factor: What's in a Name?
| Autor: | David R. Brigstock, Essam El-Din A. Moussad |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism medicine.medical_treatment Molecular Sequence Data Gene Expression Biology Biochemistry Epithelium Immediate-Early Proteins Extracellular matrix Nephroblastoma Overexpressed Protein Paracrine signalling Endocrinology Transforming Growth Factor beta Fibrosis Terminology as Topic Internal medicine Genetics medicine Animals Humans Amino Acid Sequence Nerve Tissue Growth Substances Autocrine signalling Molecular Biology Sequence Homology Amino Acid integumentary system Growth factor Connective Tissue Growth Factor Muscle Smooth Transforming growth factor beta medicine.disease Cell biology CTGF Connective Tissue CYR61 biology.protein Intercellular Signaling Peptides and Proteins Endothelium Vascular |
| Zdroj: | Molecular Genetics and Metabolism. 71:276-292 |
| ISSN: | 1096-7192 |
| DOI: | 10.1006/mgme.2000.3059 |
| Popis: | Connective tissue growth factor (CTGF) is a member of the recently described CCN gene family which contains CTGF itself, cyr61, nov, elm1, Cop1, and WISP-3. CTGF is transcriptionally activated by several factors although its stimulation by transforming growth factor beta (TGF-beta) has attracted considerable attention. CTGF acts to promote fibroblast proliferation, migration, adhesion, and extracellular matrix formation, and its overproduction is proposed to play a major role in pathways that lead to fibrosis, especially those that are TGF-beta-dependent. This includes fibrosis of major organs, fibroproliferative diseases, and scarring. CTGF also appears to play a role in the extracellular matrix remodeling that occurs in normal physiological processes such as embryogenesis, implantation, and wound healing. However, recent advances have shown that CTGF is involved in diverse autocrine or paracrine actions in several other cell types such as vascular endothelial cells, epithelial cells, neuronal cells, vascular smooth muscle cells, and cells of supportive skeletal tissues. Moreover, in some circumstances CTGF has negative effects on cell growth in that it can be antimitotic and apoptotic. In light of these discoveries, CTGF has been implicated in a diverse variety of processes that include neovascularization, transdifferentiation, neuronal scarring, atherosclerosis, cartilage differentiation, and endochondral ossification. CTGF has thus emerged as a potential important effector molecule in both physiological and pathological processes and has provided a new target for therapeutic intervention in fibrotic diseases. |
| Databáze: | OpenAIRE |
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