Cancer metabolism gets physical
| Autor: | Claudia Fischbach, Peter DelNero, Lewis C. Cantley, Benjamin D. Hopkins |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Computer science Extramural media_common.quotation_subject Fidelity General Medicine Computational biology Precision medicine Article Biophysical Phenomena Translational Research Biomedical 03 medical and health sciences Kinetics 030104 developmental biology Cell metabolism Cancer metabolism Neoplasms Tumor Microenvironment Humans Precision Medicine Personal genomics media_common |
| Popis: | Patient-derived culture models enable assessment of drug sensitivity and can connect personalized genomics with therapeutic options. However, their clinical translation is constrained by limited fidelity. We outline how the physical microenvironment regulates cell metabolism and describe how engineered culture systems could enhance the predictive power for precision medicine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|