HPLC-MS profiling of the multidrug-resistance modifying resin glycoside content of Ipomoea alba seeds
| Autor: | Jhon Castañeda-Gómez, Mabel Fragoso-Serrano, Daniel Rosas-Ramírez, Sara E. Cruz-Morales, Rogelio Pereda-Miranda |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
Chromatography biology 010405 organic chemistry Glycoside lcsh:RS1-441 Glycolipid biology.organism_classification Mass spectrometry Resin glycoside 01 natural sciences High-performance liquid chromatography HPLC–MS profiling 0104 chemical sciences Multiple drug resistance lcsh:Pharmacy and materia medica 010404 medicinal & biomolecular chemistry Ipomoea alba Biochemistry chemistry General Pharmacology Toxicology and Pharmaceutics Convolvulaceae Human breast |
| Zdroj: | Revista Brasileira de Farmacognosia v.27 n.4 2017 Revista Brasileira de Farmacognosia Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA Revista Brasileira de Farmacognosia, Vol 27, Iss 4, Pp 434-439 (2017) Revista Brasileira de Farmacognosia, Volume: 27, Issue: 4, Pages: 434-439, Published: AUG 2017 Revista Brasileira de Farmacognosia, Vol 27, Iss 4, Pp 434-439 |
| Popis: | High performance liquid chromatography profiling with mass spectrometry detection was applicable to identify known and novel multidrug-resistance glycolipid inhibitors from the complex resin glycosides mixture of Ipomoea alba L., Convolvulaceae, seeds. Albinosides X and XI were purified by recycling liquid chromatography and their structural elucidation was accomplished by nuclear magnetic resonance. Albinoside XI exerted a strong potentiation of vinblastine susceptibility in multidrug-resistant human breast carcinoma cells. Keywords: HPLC–MS profiling, Glycolipid, Resin glycoside |
| Databáze: | OpenAIRE |
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