The Pin1 gene polymorphism and the susceptibility of oral squamous cell carcinoma in East China
| Autor: | Jie Yao, Zi-Lu Wang, Jianming Wang, Yu-Nong Wu |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Cancer Research China Biology Polymorphism Single Nucleotide Genetics Humans Basal cell Genetic Predisposition to Disease Promoter Regions Genetic Gene Genetic Association Studies Aged Peptidylprolyl isomerase Protein function Heterozygote advantage General Medicine Middle Aged Peptidylprolyl Isomerase NIMA-Interacting Peptidylprolyl Isomerase Increased risk Oncology PIN1 Cancer research Carcinoma Squamous Cell Female Mouth Neoplasms Gene polymorphism |
| Zdroj: | Cancer biomarkers : section A of Disease markers. 14(6) |
| ISSN: | 1875-8592 |
| Popis: | Pin1 is a peptidylprolyl isomerase that specifically recognizes phosphorylated Pro-directed Ser/Thr (pSer/Thr-Pro) peptide sequences. Genetic variants in the Pin1 gene may alter protein function and cancer risk. In this study, we genotyped the two common promoter polymorphisms -842G/C (rs2233678) and -667T/C (rs2233679) in two independent hospital-based case-control studies conducted in Eastern Chinese populations, including 209 patients with oral squamous cell carcinoma and 444 cancer-free controls. We found -667TT heterozygotes had a significantly increased risk of oral squamous cell carcinoma (P=0.028, OR=1.66, 95%CI=1.02-2.69). However, there was no risk significant associated with the -842G/C polymorphism. Further large population-based studies are needed to confirm these results. |
| Databáze: | OpenAIRE |
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