Association of ACTN3 Polymorphism with Body Somatotype and Cardiorespiratory Fitness in Young Healthy Adults
| Autor: | Beata Penar-Zadarko, Zbigniew Barabasz, Edyta Nizioł-Babiarz, Natalia Potocka, Maria Zadarko-Domaradzka, Marcin Braun, Emilian Zadarko, Mariusz Ozimek, Izabela Zawlik, Marzena Skrzypa |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Genotype Health Toxicology and Mutagenesis lcsh:Medicine Adipose tissue Physiology Biology Article ACTN3 polymorphism Young Adult 03 medical and health sciences Oxygen Consumption 0302 clinical medicine Polymorphism (computer science) sport genetic Humans Actinin HRmax HRM PCR Genotyping 030304 developmental biology 0303 health sciences Polymorphism Genetic Somatotypes lcsh:R Public Health Environmental and Occupational Health VO2 max Cardiorespiratory fitness 030229 sport sciences Cross-Sectional Studies Cardiorespiratory Fitness health-related fitness Body Composition Female Gene polymorphism Body mass index |
| Zdroj: | International Journal of Environmental Research and Public Health, Vol 16, Iss 9, p 1489 (2019) International Journal of Environmental Research and Public Health Volume 16 Issue 9 |
| ISSN: | 1660-4601 |
| DOI: | 10.3390/ijerph16091489 |
| Popis: | ACTN3 encodes the protein &alpha actinin-3, which affects the muscle phenotype. In the present study, we examined the association of ACTN3 R577X polymorphism with body somatotype and cardiorespiratory fitness in young, healthy adults. The study group included 304 young adults, in whom cardiorespiratory fitness was evaluated and the maximum oxygen uptake was determined directly. The somatotype components were calculated according to the Heath-Carter method. Genotyping for the ACTN3 gene was performed using a polymerase chain reaction followed by high-resolution melting analysis. In the female group, a lower maximal heart rate (HRmax) was more strongly associated with the RR genotype (p = 0.0216) than with the RX and XX genotypes. In the male group, the ACTN3 RX genotype, as compared with other genotypes, tended to be associated with a lower percentage of adipose tissue (p = 0.0683), as also reflected by the body mass index (p = 0.0816). ACTN3 gene polymorphism may affect cardiorespiratory fitness. Our analysis of ACTN3 gene polymorphism does not clearly illustrate the relationships among genotype, body composition, and somatotype in young, healthy adults. |
| Databáze: | OpenAIRE |
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