In vivo plaque characterization using intravascular ultrasound-virtual histology in a porcine model of complex coronary lesions
| Autor: | Angela Builes, Carlos L. Alviar, David Wallace-Bradley, Greg L. Kaluza, Juan F. Granada, Htut K. Win, Roberto Barrios, Eli I. Lev, Daryl G. Schulz, Albert E. Raizner |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Pathology
medicine.medical_specialty Swine medicine.disease_cause Sensitivity and Specificity User-Computer Interface In vivo Adventitia Intravascular ultrasound medicine Animals Carotid Stenosis Ultrasonography Interventional Observer Variation medicine.diagnostic_test Vascular disease business.industry Ultrasound Histological Techniques Histology medicine.disease Vulnerable plaque Coronary Vessels Immunohistochemistry Disease Models Animal medicine.anatomical_structure Liposomes Linear Models Cardiology and Cardiovascular Medicine business Lipoprotein |
| Zdroj: | Arteriosclerosis, thrombosis, and vascular biology. 27(2) |
| ISSN: | 1524-4636 |
| Popis: | Objective— To determine the accuracy of detection of different tissue types of intravascular ultrasound–virtual histology (IVUS-VH) in a porcine model of complex coronary lesions. Methods and Results— Coronary lesions were induced by injecting liposomes containing human oxidized low-density lipoprotein into the adventitia of the arteries. IVUS-VH imaging was performed in vivo at 8.2±1.6 weeks after injection. A total of 60 vascular lesions were analyzed and compared with their correspondent IVUS-VH images. Correlation analysis was performed using linear regression models. Compared with histology, IVUS-VH correctly identified the presence of fibrous, fibro-fatty, and necrotic tissue in 58.33%, 38.33%, and 38.33% of lesions, respectively. The sensitivity of IVUS-VH for the detection of fibrous, fibro-fatty, and necrotic core tissue was 76.1%, 46%, and 41.1% respectively. A linear regression analysis performed for each individual plaque component did not show strong correlation that would allow significant prediction of individual values. Conclusions— In a porcine model of complex coronary lesions, IVUS-VH was not accurate in detecting the relative amount of specific plaque components within each individual corresponding histological specimen. |
| Databáze: | OpenAIRE |
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