Maternal Dietary Factors and the Risk of Autism Spectrum Disorders: A Systematic Review of Existing Evidence
Autor: | Kristen Lyall, Jillian Tessing, Brian K. Lee, Caichen Zhong |
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Rok vydání: | 2020 |
Předmět: |
Autism Spectrum Disorder
Article 03 medical and health sciences Folic Acid 0302 clinical medicine Pregnancy Risk Factors Environmental health mental disorders Vitamin D and neurology Humans Medicine 0501 psychology and cognitive sciences Vitamin B12 Vitamin D Prenatal vitamins Genetics (clinical) business.industry General Neuroscience 05 social sciences medicine.disease Causality Dietary Reference Intake Autism spectrum disorder Dietary Supplements Autism Female Neurology (clinical) business Multivitamin 030217 neurology & neurosurgery 050104 developmental & child psychology |
Zdroj: | Autism Res |
ISSN: | 1939-3806 1939-3792 |
Popis: | Prenatal maternal diet is a critical factor in offspring neurodevelopment. Emerging evidence suggests that prenatal diet may also play a role in the etiology autism spectrum disorder (ASD). This review summarizes studies published in English that examined prenatal nutrients or maternal diet in association with ASD from PubMed as of July 2020. Thiry-six studies from nine countries were included in this systematic review; these focused on multivitamin (n = 5), prenatal vitamin (n = 3), folic acid (FA; n = 14), Vitamin D (n = 11), polyunsaturated fatty acid or fish/supplement intake (n = 7), iron (n = 3), Vitamin B12 (n = 1), calcium (n = 1), magnesium (n = 1), and broad maternal dietary habits (n = 3). Overall, higher or moderate intake of prenatal/multivitamin, FA, and Vitamin D was associated with reductions in odds of ASD, though results have not been uniform and there is a need to clarify differences in findings based on biomarkers versus reported intake. Evidence was inconclusive or insufficient for other nutrients. Differences in the timing and measurement of these dietary factors, as well as potential residual confounding, may contribute to existing discrepancies. Key areas for future research to better understand the role of maternal diet in ASD include the need to address potential critical windows, examine the combined effect of multiple nutrients, and consider interactions with genetic or environmental factors. LAY SUMMARY: Maternal diet during pregnancy is important for child neurodevelopment. We reviewed 36 studies examining maternal diet and autism spectrum disorder (ASD) and found that prenatal vitamin/multivitamin use and adequate intake of folic acid and Vitamin D were each associated with lower likelihood of having a child with ASD. Future studies on these and other dietary factors are needed to better understand the role of maternal diet in the development of ASD. Autism Res 2020, 13: 1634-1658. © 2020 International Society for Autism Research and Wiley Periodicals LLC. |
Databáze: | OpenAIRE |
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