BIOLOGICAL ACTIVITIES OF HAMYCIN
| Autor: | A. C. Maniar, Sarala Mavdikar |
|---|---|
| Rok vydání: | 1966 |
| Předmět: |
Antifungal Agents
Globulin Ovalbumin Immunology Pharmacology Applied Microbiology and Biotechnology Microbiology Mice chemistry.chemical_compound Amphotericin B Genetics medicine Animals Humans Candicidin Candida albicans Lung Molecular Biology Serum Albumin Candida Cryptococcus neoformans biology Antifungal antibiotic Albumin Serum Albumin Bovine General Medicine biology.organism_classification Cryptococcus Suicide Biochemistry chemistry biology.protein Hamycin medicine.drug |
| Zdroj: | Canadian Journal of Microbiology. 12:377-384 |
| ISSN: | 1480-3275 0008-4166 |
| DOI: | 10.1139/m66-051 |
| Popis: | After ad ministration of an oral dose to mice, hamycin, an antifungal antibiotic, penetrated the body tissues and eliminated Cryptococcus neoformans present in the lungs. Out of 11 polyenes (hamycin, aureofungin, trichomycin, etruscomycin, amphotericin B, pimaricin, mycostatin, candidin, candicidin, PA150, and filipin), hamycin and aureofungin showed the highest "in vitro" activity against Candida albicans. The antifungal activity of hamycin, PA150, and aureofungin was increased by the addition of serum, plasma, or crystalline albumins. This increase in activity can be used as an additional characteristic to differentiate some of the polyenes. We now believe that serum was responsible for our previous findings that "high concentrations of hamycin in the organs of mice were detected". It has been shown that the complete albumin molecule was required to increase the activity of hamycin. The possibility that serum globulins or other proteins may increase the hamycin activity is not ruled out by our experiments. |
| Databáze: | OpenAIRE |
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