T cell subsets In peripheral blood and cerebrospinal fluid from children with aseptic meningitis
| Autor: | Nobutada Tabata, Yoshihiro Komada, Nakao Sakurai, Kumiko Morita, Yukio Shogo, Kaichi Oitani, Yan-Wen Zhou, Shao-Li Zhang |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Pathology
medicine.medical_specialty CD8 Antigens CD3 T cell Cerebrospinal fluid T-Lymphocyte Subsets Humans Medicine Meningitis Aseptic Child biology business.industry Antibodies Monoclonal Aseptic meningitis HLA-DR Antigens medicine.disease medicine.anatomical_structure Child Preschool CD4 Antigens Pediatrics Perinatology and Child Health biology.protein Antibody Subarachnoid space business Meningitis CD8 |
| Zdroj: | Pediatrics International. 36:632-636 |
| ISSN: | 1328-8067 |
| Popis: | T cell subsets in peripheral blood (PB) and cerebrospinal fluid (CSF) obtained from patients with aseptic meningitis were studied using quantitative two-color fluorescence analysis with a flow cytometer. The percentage of HLA-DR+/CD3+ lymphocytes (activated T cells) in CSF was significantly increased in the recovery phase when compared to the acute phase, while no significant change in the activated T cells in PB was observed. More interestingly, CD4+ T lymphocytes in CSF were increased in the acute phase and subsequently decreased in the recovery phase. Instead, CD8+ T lymphocytes gradually accumulated into the CSF in the recovery phase, resulting in a successive decrease in the CD4/CD8 ratio. On the other hand, the CD4/CD8 ratio in PB remained normal during the course of aseptic meningitis. The present results suggest that T lymphocytes (CD4+ subset in the acute phase and CD8+ in the recovery phase) could be infiltrated and further activated at the site of inflammation, possibly in the subarachnoid space in the patients with aseptic meningitis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text