The effect of coexisting autoimmune thyroiditis in children with Type 1 diabetes on optical coherence tomography results
| Autor: | Byczyńska Aleksandra, Wysocka-Mincewicz Marta, Hautz Wojciech, Olechowski Andrzej, Gołębiewska Joanna, Baszyńska-Wilk Marta, Szalecki Mieczysław |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Gastroenterology Retina Autoimmune thyroiditis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Internal Medicine medicine Humans Prospective Studies 030212 general & internal medicine Child Autoimmune disease Type 1 diabetes business.industry Angiography Thyroiditis Autoimmune Reproducibility of Results Retinal Diabetic retinopathy medicine.disease Diabetes Mellitus Type 1 chemistry Free triiodothyronine Pediatrics Perinatology and Child Health Mann–Whitney U test Female business Tomography Optical Coherence Hormone |
| Zdroj: | Pediatric Diabetes. 22:329-334 |
| ISSN: | 1399-5448 1399-543X |
| DOI: | 10.1111/pedi.13154 |
| Popis: | OBJECTIVE To assess the influence of thyroid hormones status and coexistence of autoimmune thyroiditis on optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) results in children with Type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS In the prospective, observational study (n = 175) we analyzed the impact of thyroid hormones on OCT results and the differences between the matched groups of children with T1D (n = 84; age = 13.14 ± 3.6; diabetes duration = 5.99 ± 3.3 years) and the children with T1D and autoimmune thyroiditis (AT) (n = 20; age = 13.94 ± 3.6; diabetes duration = 6.7 ± 4 years). We analyzed the following parameters: fovea avascular zone (FAZ), foveal thickness (FT), parafoveal thickness (PFT), ganglion cell complex (GCC), loss volume (global-GLV, focal-FLV), capillary vessel density: superficial (whole-wsVD, foveal-fsVD, parafoveal-psVD), and deep (whole-wdVD, foveal-fdVD, parafoveal-pdVD. The differences between the groups were tested by the unpaired t-Student test, Mann-Whitney U test as appropriate, whereas p level .05 was recognized as significant. RESULTS We detected the significant correlations between thyroid-stimulating hormone (TSH) level and PFT (r = -0.14; p |
| Databáze: | OpenAIRE |
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