Effects of bolesatine on a cell line from the SP2/O thymic lymphosarcoma
| Autor: | R. Ennamany, E.E. Creppy, L. Basset, Gérard Deffieux, J.P. Portail, O. Kretz, A. Badoc, B. Guillemain |
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| Rok vydání: | 1995 |
| Předmět: |
Male
Neoplasms Radiation-Induced Cell Survival Ratón Biology Toxicology medicine.disease_cause Median lethal dose Fungal Proteins Lethal Dose 50 Mice In vivo Tumor Cells Cultured medicine Animals IC50 Protein Synthesis Inhibitors Mice Inbred BALB C Fungal protein Protein synthesis inhibitor Dose-Response Relationship Drug Toxin Lymphoma Non-Hodgkin Lethal dose Thymus Neoplasms Mycotoxins Molecular biology Kinetics Immunology Female Cell Division Injections Intraperitoneal |
| Zdroj: | Toxicology. 103:121-125 |
| ISSN: | 0300-483X |
| DOI: | 10.1016/0300-483x(95)03113-t |
| Popis: | Bolesatine, a toxic protein isolated from Boletus satanas Lenz inhibits in vitro protein synthesis in a concentration-dependent manner in a cell line from a radiation-induced thymic lymphosarcoma (SP2/O) with a 50% inhibitory concentration (IC50) of 9.5 nM (0.6 microgram/ml). In vivo, an i.p. single injection of bolesatine, corresponding to 1/6 and 1/10 of 24-h 50% lethal dose, in Balb/c mice having ascitic tumour induced by the i.p. preinjection of SP2/O cells allows a remission of 50% and 30%, respectively. Treated mice survived 120 days after the treatment, i.e. 90 days after the death of control animals. |
| Databáze: | OpenAIRE |
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