Genome-wide association study provides insights into genes related with horn development in Nelore beef cattle
| Autor: | Nedenia Bonvino Stafuzza, Daniela Lourenco, Rafael Medeiros de Oliveira Silva, Cláudio de Ulhôa Magnabosco, Fernando A. Di Croce, Elisa Peripolli, Raysildo Barbosa Lôbo, Luiz Antonio Framartino Bezerra, Jason B. Osterstock, Danísio Prado Munari, Fernando Baldi |
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| Přispěvatelé: | Nedenia Bonvino Stafuzza, UNESP, Rafael Medeiros de Oliveira Silva, University of Georgia, ELISA PERIPOLLI, UNESP, Luiz Antônio Framartino Bezerra, USP, Raysildo Barbosa Lôbo, Associaçao Nacional dos Criadores e Pesquisadores, CLAUDIO DE ULHOA MAGNABOSCO, CPAC, Fernando Di Croce, Zoetis, Jason Osterstock, Zoetis, Danísio Prado Munari, UNESP, Daniela A. Lino Lourenco, University of Georgia, Fernando Baldi, UNESP., Universidade Estadual Paulista (Unesp), University of Georgia, United States Department of Agriculture (USDA), Universidade de São Paulo (USP), Associaçao Nacional dos Criadores e Pesquisadores (ANCP), Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA), Zoetis |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Population lcsh:Medicine Single-nucleotide polymorphism Genome-wide association study Locus (genetics) Breeding Biology Runs of Homozygosity Polymorphism Single Nucleotide Genome 03 medical and health sciences Animals SNP Allele lcsh:Science education Mutação Horns Genetics education.field_of_study Multidisciplinary Bos Indicus FENÓTIPOS lcsh:R Homozygote Gado Nelore Red Meat Phenotype 030104 developmental biology lcsh:Q Cattle Genome-Wide Association Study |
| Zdroj: | Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA-Alice) Empresa Brasileira de Pesquisa Agropecuária (Embrapa) instacron:EMBRAPA Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP PLoS ONE, Vol 13, Iss 8, p e0202978 (2018) |
| Popis: | Made available in DSpace on 2018-12-11T17:22:31Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-08-01 The causal mutation for polledness in Nelore (Bos taurus indicus) breed seems to have appeared first in Brazil in 1957. The expression of the polled trait is known to be ruled by a few groups of alleles in taurine breeds; however, the genetic basis of this trait in indicine cattle is still unclear. The aim of this study was to identify genomic regions associated with the hornless trait in a commercial Nelore population. A total of 107,294 animals had phenotypes recorded and 2,238 were genotyped/imputed for 777k SNP. The weighted single-step approach for genome-wide association study (WssGWAS) was used to estimate the SNP effects and variances accounted for by 1 Mb sliding SNP windows. A centromeric region of chromosome 1 with 3.11 Mb size (BTA1: 878,631–3,987,104 bp) was found to be associated with hornless in the studied population. A total of 28 protein-coding genes are mapped in this region, including the taurine Polled locus and the IFNAR1, IFNAR2, IFNGR2, KRTAP11-1, MIS18A, OLIG1, OLIG2, and SOD1 genes, which expression can be related to the horn formation as described in literature. The functional enrichment analysis by DAVID tool revealed cytokine-cytokine receptor interaction, JAK-STAT signaling, natural killer cell mediated cytotoxicity, and osteoclast differentiation pathways as significant (P < 0.05). In addition, a runs of homozygosity (ROH) analysis identified a ROH island in polled animals with 2.47 Mb inside the region identified by WssGWAS. Polledness in Nelore cattle is associated with one region in the genome with 3.1 Mb size in chromosome 1. Several genes are harbored in this region, and they may act together in the determination of the polled/horned phenotype. Fine mapping the locus responsible for polled trait in Nelore breed and the identification of the molecular mechanisms regulating the horn growth deserve further investigation. Departamento de Ciencias Exatas Faculdade de Ciencias Agrarias e Veterinarias (FCAV) Universidade Estadual Paulista Julio de Mesquita Filho (UNESP) Department of Animal and Dairy Science University of Georgia National Center for Cool and Cold Water Aquaculture (NCCCWA) Agricultural Research Service (ARS) United States Department of Agriculture (USDA) Departamento de Zootecnia Faculdade de Ciencias Agrarias e Veterinarias (FCAV) Universidade Estadual Paulista Julio de Mesquita Filho (UNESP) Departamento de Genetica Faculdade de Medicina de Ribeirao Preto (FMRP) Universidade de Sao Paulo (USP) Associaçao Nacional dos Criadores e Pesquisadores (ANCP) Empresa Brasileira de Pesquisa Agropecuaria (EMBRAPA) Zoetis Departamento de Ciencias Exatas Faculdade de Ciencias Agrarias e Veterinarias (FCAV) Universidade Estadual Paulista Julio de Mesquita Filho (UNESP) Departamento de Zootecnia Faculdade de Ciencias Agrarias e Veterinarias (FCAV) Universidade Estadual Paulista Julio de Mesquita Filho (UNESP) |
| Databáze: | OpenAIRE |
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