Investigation of genotoxic and antigenotoxic activities of Melampodium divaricatum in Salmonella typhimurium
| Autor: | Lourdes Campaner dos Santos, Cássia Regina Primila Cardoso, Eliana Aparecida Varanda, Maira Eiko Ikuma Nogueira, Mariana Henrique Passoni, Fabiana Izilda Biso, Maria do Carmo Longo |
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| Rok vydání: | 2005 |
| Předmět: |
Chlorophyll
Salmonella typhimurium Aflatoxin Salmonella Aflatoxin B1 Flowers Asteraceae Toxicology medicine.disease_cause Terpene Botany medicine Benzo(a)pyrene Animals Calendula Medicinal plants biology Traditional medicine Dose-Response Relationship Drug Mutagenicity Tests Plant Extracts fungi Daunorubicin food and beverages Antimutagenic Agents General Medicine biology.organism_classification Triterpenes Anti-Bacterial Agents Rats Calendula officinalis Mutation Microsome Chromatography Thin Layer DNA Damage Mutagens |
| Zdroj: | Toxicology in vitro : an international journal published in association with BIBRA. 20(3) |
| ISSN: | 0887-2333 |
| Popis: | Melampodium divaricatum is a member of the Asteraceae and in Brazil is known as false-calendula, its flowers being used in anti-inflammatory preparations, substituting the true calendula or marigold (Calendula officinalis L.). The flower extract was investigated for mutagenic and antimutagenic effect in the Salmonella/microsome assay. The tested extract was not mutagenic in the strains TA100, TA98, TA97a and TA102 and decreased the mutagenicity of aflatoxin B1, benzo(a)pyrene and daunomycin. Chlorophyll and triterpenes were detected in the extract, and they might have contributed to the observed effect. Our data suggest that these medicinal plants possess cancer chemopreventive properties. |
| Databáze: | OpenAIRE |
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