Biochemistry of blood plasma and some parameters of antioxidant status in rats with polyhypovitaminosis of varying severity
| Autor: | O. A. Vrzhesinskaya, Karagodina Zv, Beketova Na, S Kh Soto, Kodentsova Vm, N. E. Sharanova, V. A. Baturina |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Antioxidant Ubiquinone medicine.medical_treatment Ascorbic Acid General Biochemistry Genetics and Molecular Biology Antioxidants chemistry.chemical_compound Internal medicine Blood plasma medicine Animals Rats Wistar Coenzyme Q10 Calcium metabolism Vitamin C Avitaminosis General Medicine Ascorbic acid Rats Endocrinology chemistry Biochemistry Liver Alkaline phosphatase Uric acid Lipid Peroxidation |
| Zdroj: | Bulletin of experimental biology and medicine. 154(4) |
| ISSN: | 1573-8221 |
| Popis: | In rats with profound vitamin deficiency, blood plasma level of triglycerides significantly decreased by 1.6 times, potassium ions by 5%, uric acid by 23%, ALT and AST by 1.4 times, while the levels of glucose increased by 32%, iron by 31%, urea by 58%, and alkaline phosphatase by 19%. Plasma level of phosphorus tended to decrease and ionized calcium concentration tended to increase. Severe deficiency of all vitamins is accompanied by pronounced accumulation of MDA in the plasma and liver together with simultaneous increase in the level of coenzyme Q10 by 4.6 times and decrease in vitamin C content by 21.4% in the rat liver compared to the control. It was found that severe combined deficiency of vitamins for 4 weeks produced considerable multidirectional alterations in diagnostically important metabolic parameters in rat plasma. |
| Databáze: | OpenAIRE |
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