Active site directed inhibitors of replication-specific bacterial DNA polymerases

Autor:	George E. Wright, Zheng-yu Long, Marjorie H. Barnes, Michelle M. Butler, Chengxin Zhi, Joseph Gambino, Wei-Chu Xu, Neal C. Brown
Rok vydání:	2005
Předmět:	DNA Replication Guanine Gram-negative bacteria DNA polymerase Gram-positive bacteria Clinical Biochemistry Pharmaceutical Science Gram-Positive Bacteria Binding Competitive Biochemistry Structure-Activity Relationship Bacterial Proteins Gram-Negative Bacteria Drug Discovery Humans Uracil Molecular Biology Polymerase DNA Polymerase III Nucleic Acid Synthesis Inhibitors Antibacterial agent chemistry.chemical_classification Binding Sites biology Chemistry Organic Chemistry DNA replication biology.organism_classification Molecular biology Kinetics Enzyme biology.protein Molecular Medicine Bacteria
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 15:729-732
ISSN:	0960-894X
DOI:	10.1016/j.bmcl.2004.11.016
Popis:	7-Substituted-N(2)-(3,4-dichlorobenzyl)guanines potently and competitively inhibit DNA polymerases IIIC and IIIE from Gram(+) bacteria. Certain derivatives are also competitive inhibitors of DNA polymerase IIIE from Gram(-) bacteria.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4783294df115458ba9346baba8f84f95 https://doi.org/10.1016/j.bmcl.2004.11.016 Zobrazit plný text záznamu Full Text from ScienceDirect