Comparison between resected and irradiated small cell lung cancer in patients in stages I through IIIa
| Autor: | Masayuki Kawasaki, Shinzo Takamori, Mitsuo Ohta, Kazuo Hata, Yukito Ichinose, Nobuyuki Hara |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine medicine.medical_specialty Lung Neoplasms medicine.medical_treatment Pulmonary function testing Pneumonectomy medicine Carcinoma Humans Carcinoma Small Cell Stage (cooking) Survival rate Aged Neoplasm Staging Chemotherapy Brain Neoplasms business.industry Respiratory disease Neoplasms Second Primary Middle Aged medicine.disease Surgery Survival Rate Radiation therapy Female Neoplasm Recurrence Local Cardiology and Cardiovascular Medicine business |
| Zdroj: | The Annals of Thoracic Surgery. 53:95-100 |
| ISSN: | 0003-4975 |
| DOI: | 10.1016/0003-4975(92)90765-v |
| Popis: | The survival and recurrence of 37 patients with small cell lung cancer who underwent surgical resection were compared with those of 32 patients who were excluded from surgical resection but received radiotherapy. All but 2 patients received chemotherapy. The number of patients in the resected and nonresected groups in each pretreatment clinical stage were, respectively, as follows: 13 and 2 in stage I, 12 and 7 in stage II, and 12 and 23 in stage IIIa. The main reasons for exclusion from surgical resection were locally advanced disease in 15 patients, avoidance of pneumonectomy in 7, and poor pulmonary function in 5. In stage II, the mean tumor size was larger and there were fewer patients with peripheral tumors in the nonresected group than in the resected group. In stage IIIa, there were significantly more patients with overt N2 disease and central tumors in the nonresected group than in the resected group. The 5-year survival rate of the resected group in stage I was 67.7%. Although the nonresected group in stages II and IIIa had many adverse prognostic factors, there was no statistically significant difference between the survival of the resected and the nonresected groups. With respect to the site of first recurrence, a similar pattern was observed in the two groups in each stage, whereas local disease in stage I was completely controlled by surgical resection. These observations suggest that surgical resection can be considered a modality of treatment in clinical stage I. However, the treatment role of surgical resection in clinical stages II and IIIa, even in selected patients, remains unclear. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|