Hypothyroidism reduces ObRb–STAT3 leptin signalling in the hypothalamus and pituitary of rats associated with resistance to leptin acute anorectic action
| Autor: | Luana L. Souza, Norma Aparecida dos Santos Almeida, Carmen Cabanelas Pazos-Moura, Ricardo H. Costa-e-Sousa, Isis Hara Trevenzoli, Camila Calvino |
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| Rok vydání: | 2012 |
| Předmět: |
Leptin
Male STAT3 Transcription Factor endocrine system medicine.medical_specialty Pituitary gland endocrine system diseases Endocrinology Diabetes and Metabolism Drug Resistance Hypothalamus Down-Regulation Thyrotropin Eating Endocrinology Hypothyroidism Internal medicine Animals Medicine Euthyroid SOCS3 Rats Wistar Receptor Leptin receptor business.industry digestive oral and skin physiology Anorexia Rats medicine.anatomical_structure Pituitary Gland Acute Disease Anorectic Receptors Leptin business hormones hormone substitutes and hormone antagonists Signal Transduction |
| Zdroj: | Journal of Endocrinology. 215:129-135 |
| ISSN: | 1479-6805 0022-0795 |
| Popis: | Leptin has been shown to regulate the hypothalamus–pituitary–thyroid axis, acting primarily through the STAT3 pathway triggered through the binding of leptin to the long-chain isoform of the leptin receptor, ObRb. We previously demonstrated that although hyperthyroid rats presented leptin effects on TSH secretion, those effects were abolished in hypothyroid rats. We addressed the hypothesis that changes in the STAT3 pathway might explain the lack of TSH response to leptin in hypothyroidism by evaluating the protein content of components of leptin signalling via the STAT3 pathway in the hypothalamus and pituitary of hypothyroid (0.03% methimazole in the drinking water/21 days) and hyperthyroid (thyroxine 5 μg/100 g body weight /5 days) rats. Hypothyroid rats exhibited decreased ObRb and phosphorylated STAT3 (pSTAT3) protein in the hypothalamus, and in the pituitary gland they exhibited decreased ObRb, total STAT3, pSTAT3 and SOCS3 (P |
| Databáze: | OpenAIRE |
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