Recent Advances in Anti-virulence Therapeutic Strategies With a Focus on Dismantling Bacterial Membrane Microdomains, Toxin Neutralization, Quorum-Sensing Interference and Biofilm Inhibition
| Autor: | Octavio L. Franco, Marlon H. Cardoso, Suzana M. Ribeiro, Osmel Fleitas Martínez |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Microbiology (medical) antibiotic resistance Virulence Factors 030106 microbiology Immunology Biofilm inhibition lcsh:QR1-502 Virulence Review Computational biology Biology medicine.disease_cause Microbiology lcsh:Microbiology Neutralization 03 medical and health sciences Cellular and Infection Microbiology Antibiotic resistance Membrane Microdomains Drug Discovery medicine Bacterial Toxin Neutralization bacterial toxins Bacteria Toxin Biofilm Quorum Sensing anti-virulence therapy Anti-Bacterial Agents Quorum sensing 030104 developmental biology Infectious Diseases Biofilms bacterial membrane microdomains |
| Zdroj: | Frontiers in Cellular and Infection Microbiology Frontiers in Cellular and Infection Microbiology, Vol 9 (2019) |
| ISSN: | 2235-2988 |
| Popis: | Antimicrobial resistance constitutes one of the major challenges facing humanity in the Twenty-First century. The spread of resistant pathogens has been such that the possibility of returning to a pre-antibiotic era is real. In this scenario, innovative therapeutic strategies must be employed to restrict resistance. Among the innovative proposed strategies, anti-virulence therapy has been envisioned as a promising alternative for effective control of the emergence and spread of resistant pathogens. This review presents some of the anti-virulence strategies that are currently being developed, it will cover strategies focused on quench pathogen quorum sensing (QS) systems, disassemble of bacterial functional membrane microdomains (FMMs), disruption of biofilm formation and bacterial toxin neutralization. |
| Databáze: | OpenAIRE |
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