Improvement of Heart Redox States Contributes to the Beneficial Effects of Selenium Against Penconazole-Induced Cardiotoxicity in Adult Rats

Autor: Safa Hamdi, Raoudha Ellouze Ghorbel, Tahia Boudawara, Mariem Chaâbane, Nejla Soudani, Najiba Zeghal, Meriem Tir, Kamel Jamoussi, Ons Boudawara
Rok vydání: 2015
Předmět:
Male
0301 basic medicine
medicine.medical_specialty
Antioxidant
Endocrinology
Diabetes and Metabolism
medicine.medical_treatment
Clinical Biochemistry
010501 environmental sciences
medicine.disease_cause
01 natural sciences
Biochemistry
Antioxidants
Protein Carbonylation
Inorganic Chemistry
Superoxide dismutase
Selenium
03 medical and health sciences
chemistry.chemical_compound
Internal medicine
medicine
Animals
Rats
Wistar
0105 earth and related environmental sciences
chemistry.chemical_classification
medicine.diagnostic_test
Vitamin C
biology
Myocardium
Glutathione peroxidase
Biochemistry (medical)
Heart
General Medicine
Glutathione
Triazoles
Malondialdehyde
Cardiotoxicity
Fungicides
Industrial
Oxidative Stress
030104 developmental biology
Endocrinology
chemistry
biology.protein
Lipid Peroxidation
Lipid profile
Oxidative stress
Zdroj: Biological Trace Element Research. 169:261-270
ISSN: 1559-0720
0163-4984
DOI: 10.1007/s12011-015-0426-0
Popis: The present study was performed to evaluate the protective effect of selenium (Se) against penconazole (PEN)-induced oxidative stress in the cardiac tissue of adult rats. Male Wistar rats were divided into four groups of six each. The first group represented the controls. For the second group (PEN), no treatment was performed during the first 6 days, and then, the rats received intraperitoneally 67 mg/kg body weight (bw) of PEN every 2 days from day 7 until day 15, the sacrifice day. For the third group (Se + PEN), Se was administered daily through the diet at a dose of 0.5 mg/kg of diet for 15 days. Rats of this group received also every 2 days PEN (67 mg/kg bw) from day 7 until day 15. The fourth group (Se) received daily, through the diet, Se (0.5 mg/Kg of diet) during 15 days. Our results showed that Se reduced significantly the elevated cardiac levels of malondialdehyde and protein carbonyl following PEN treatment, and attenuated DNA fragmentation induced by this fungicide. In addition, Se modulated the alterations of antioxidant status: enzymatic (superoxide dismutase, glutathione peroxidase, and catalase) and nonenzymatic (glutathione and vitamin C) antioxidants in the heart of PEN-treated rats. This trace element was also able to alleviate perturbations of lipid profile. The protective effect of selenium was further evident through the histopathological changes produced by PEN in the heart tissue. Taken together, our results indicated that Se might be beneficial against PEN-induced cardiac oxidative damage in rats.
Databáze: OpenAIRE
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