Comparative evaluation of biphasic insulin with metformin and triple oral hypoglycemic agents (OHA) in type 2 diabetes patients
| Autor: | Moteb Khobrani, Abdulaziz Alhossan, Sultan M. Alshahrani, C. K. Dhanapal, Noohu Abdullah Khan, Sirajudeen Shaik Alavudeen, Javid Iqbal Mir |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
endocrine system diseases medicine.medical_treatment Pharmaceutical Science 030209 endocrinology & metabolism Type 2 diabetes Gastroenterology Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Diabetes mellitus Glycaemic control medicine Biphasic insulin 030212 general & internal medicine Glycemic Pharmacology business.industry Insulin lcsh:RM1-950 Type 2 Diabetes Mellitus nutritional and metabolic diseases medicine.disease Metformin Regimen lcsh:Therapeutics. Pharmacology chemistry Oralhypoglycemic agents Glycated hemoglobin business medicine.drug |
| Zdroj: | Saudi Pharmaceutical Journal, Vol 28, Iss 2, Pp 210-214 (2020) Saudi Pharmaceutical Journal : SPJ |
| ISSN: | 1319-0164 |
| Popis: | Introduction: The prevalence of secondary failure to oral hypoglycemic agents among type 2 diabetes mellitus (T2DM) patients ranges from 30 to 60%. The alternative approaches to overcome this issue are either switching to triple oral hypoglycemic agents (OHA) or intensifying the regimen by adding insulin. Objective: To compare the glycemic control achieved with biphasic insulin plus metformin and triple OHA in T2DM patients who were not adequately controlled with two OHA regimen. Methods: A qualitative prospective study was conducted at Asir diabetes center, Abha, KSA. Poorly controlled T2DM patients with two OHA for at least 1 year with glycated hemoglobin (HbA1c) >7.0% were included. Subjects were divided into group I (a third OHA was added to the existing two OHA regimen) and group II (switched over to Biphasic insulin and metformin). At baseline and 3-month intervals, level of HbA1C, Fasting Plasma Glucose (FPG), Postprandial Plasma Glucose (PPG), Blood Pressure (BP), lipid profile and hypoglycemic episodes were obtained and evaluated for one year. Results: 41.1% of patients were in group I and 58.9% were in group II. At the end of the study, there was a significant reduction in HbA1c in group II subjects comparing to group I (8.18 ± 1.32 vs 8.79 ± 1.81, p = 0.0238). FPG and PPG were improved also in group II. The mean body weight increased from baseline in group II is +4.48 kg and decreased from baseline in group I (−0.46 kg). 11.3% from group I and 23.7% from group II reported hypoglycaemic incidences. Conclusion: Biphasic insulin and metformin regimen could be an appropriate therapeutic option for achieving good glycemic control compared with triple OHA in patients with two OHA failure. Keywords: Glycaemic control, Type 2 diabetes, Biphasic insulin, Metformin, Oralhypoglycemic agents |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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