Acute Effects of Oxazepam, Diazepam and Methylperone, alone and in Combination with Alcohol on Sedation, Coordination and Mood
| Autor: | Christina Duvhök, Lars Molander |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.drug_class Sedation Emotions Alcohol Pharmacology Toxicology Placebo Flicker Fusion chemistry.chemical_compound Piperidines medicine Humans Attention Drug Interactions Diazepam Ethanol Oxazepam Middle Aged Butyrophenones Tranquilizing Agents chemistry Motor Skills Sedative Depressant medicine.symptom medicine.drug |
| Zdroj: | Acta Pharmacologica et Toxicologica. 38:145-160 |
| ISSN: | 0001-6683 |
| DOI: | 10.1111/j.1600-0773.1976.tb03107.x |
| Popis: | Effects on critical flicker fusion frequency (CFFF), coordination and mood were studied after single oral doses of placebo, alcohol (0.5 ml ethanol/kg b. wt.), oxazepam (10, 20 and 40 mg), diazepam (5, 10, 20 and 40 mg) and methylperone (10, 25 and 50 mg), given either alone, or simultaneously with alcohol or with delayed alcohol administration. Methylperone was found to have a depressant effect similar to or greater (on a weight basis) than that of diazepam and oxazepam respectively. The correlation between sedative and antianxiety effect is discussed. The decrease in CFFF was parallelled by a decreased coordination ability. Alcohol alone had no effect on our parameters, but when given simultaneously with the drugs, it markedly increased the effect of diazepam, while the effect of oxazepam and methylperone were affected to a much lesser degree. The effect of the drugs on psychomotor skills and the interaction between alcohol and the drugs have important implications when treating out-patients. Methylperone as a potential anti-anxiety agent is discussed. |
| Databáze: | OpenAIRE |
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