A functional autoantibody in narcolepsy
| Autor: | Petra J. Neufing, Michael W. Jackson, Anthony J.F. Smith, R D McEvoy, Tom P. Gordon |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_specialty Carbachol Stimulation Cholinergic Agonists In Vitro Techniques medicine.disease_cause Synaptic Transmission Muscarinic agonist Autoimmunity Mice Parasympathetic Nervous System HLA-DQ Antigens Internal medicine medicine Animals HLA-DQ beta-Chains Humans Aged Autoantibodies Narcolepsy Mice Inbred BALB C Membrane Glycoproteins business.industry Autoantibody Muscle Smooth General Medicine Middle Aged medicine.disease Endocrinology Immunoglobulin G Immunology Cholinergic Female business Acetylcholine Muscle Contraction medicine.drug |
| Zdroj: | The Lancet. 364:2122-2124 |
| ISSN: | 0140-6736 |
| Popis: | Narcolepsy is widely believed to have an autoimmune basis, but conventional immunological approaches have failed to detect a serum autoantibody marker. Since cholinergic hyperactivity is a feature of narcolepsy-cataplexy, we transferred IgG from nine patients with narcolepsy and nine healthy controls to mice and assessed the effect on smooth muscle contractile responses to cholinergic stimulation. IgG from all narcolepsy patients significantly enhanced bladder contractile responses to the muscarinic agonist carbachol and to neuronally released acetylcholine compared with control IgG (p0.0001), whereas contraction of the sympathetically innervated vas deferens was unaltered. Our findings provide direct evidence for the autoimmune hypothesis of narcolepsy. |
| Databáze: | OpenAIRE |
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