Prognostic implications of securin expression and sub-cellular localization in human breast cancer
| Autor: | Teijo Kuopio, Eliisa Löyttyniemi, J Anttinen, Kati Talvinen, Pauliina Kronqvist, Heli Repo, Natalia Gurvits, Marjukka Nykänen |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
0301 basic medicine Oncology Cancer Research medicine.medical_specialty Fluorescent Antibody Technique Breast Neoplasms Kaplan-Meier Estimate CDC20 03 medical and health sciences 0302 clinical medicine Breast cancer Internal medicine Biomarkers Tumor medicine Humans Cellular localization Aged Proportional Hazards Models business.industry Cancer General Medicine Middle Aged Cell cycle Prognosis medicine.disease Immunohistochemistry Securin 030104 developmental biology Tissue Array Analysis 030220 oncology & carcinogenesis Cancer cell Molecular Medicine Female business |
| Zdroj: | Cellular Oncology. 39:319-331 |
| ISSN: | 2211-3436 2211-3428 |
| DOI: | 10.1007/s13402-016-0277-5 |
| Popis: | Securin belongs to a class of cell cycle regulators that prevent metaphase-to-anaphase transition until sister chromatid separation is complete. Evidence is accumulating that securin has a prognostic impact on a variety of malignancies but, thus far, the role and regulation of securin expression and its sub-cellular localization have not been systematically addressed in breast cancer. In total 470 breast cancer specimens with follow-up data for up to 22 years were included. Immunohistochemical staining and immunofluorescence double-staining were performed for securin and its regulating proteins PTTG1IP, CDC20 and BUBR1. Prognostic associations were evaluated between the expression patterns of these proteins and established prognosticators of invasive breast cancer and patient survival. We found that a high fraction of securin expressing cancer cells predicted an unfavorable clinical outcome of the breast cancer patients (p |
| Databáze: | OpenAIRE |
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