A Prospective Study on Exchange Transfusion in Neonatal Unconjugated Hyperbilirubinemia--in a Tertiary Care Hospital, Nepal
| Autor: | Brijesh Sathian, P Poudyal, KK Malla, Sandip Kumar Singh, Tejesh Malla, G Bk |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Anemia medicine.medical_treatment Exchange Transfusion Whole Blood Exchange transfusion Jaundice ABO Blood-Group System Sepsis 03 medical and health sciences 0302 clinical medicine Nepal 030225 pediatrics ABO blood group system medicine Humans 030212 general & internal medicine Prospective Studies Unconjugated hyperbilirubinemia Hematologic Tests Rh-Hr Blood-Group System medicine.diagnostic_test business.industry Tertiary Healthcare Infant Newborn Complete blood count General Medicine medicine.disease Surgery Kernicterus medicine.symptom Hyperbilirubinemia Neonatal business |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1812-2078 |
| Popis: | Background An exchange transfusion involves replacing patient’s blood with donor blood in order to remove abnormal blood components and circulating toxins while maintaining adequate circulating blood volume.Objective To observe the incidence, causes of jaundice requiring Exchange and any adverse event of exchange transfusion in newborns with unconjugated hyperbilirubinemia.Method Prospective study undertaken at Neonatal Intensive Care Unit (NICU) of Manipal Teaching Hospital, Pokhara, Nepal from March 2014 to April 2015. For both mothers and neonates blood group and Rh typing and for all newborns pre and post exchange complete blood count with peripheral smear, serum bilirubin, hemoglobin, calcium, potassium, random blood sugar, C-reactive protein and blood culture and where ever required Direct Coombs test, reticulocyte count, G6PD activity and thyroid function test were done. The incidence, indications, positive outcome, complications and mortality were noted.Result Out of 481 cases of unconjugated hyperbilirubinemia 29(6%) required exchange transfusion. 55.2% Pathological Jaundice [13.8% ABO incompatibility, sepsis and hypothyroidism was commonest causes] and 44.8% exaggerated physiological jaundice [27.6% with no underlying pathology, 10.3% preterms 3.4% cephalhematoma] required exchange transfusion. Post transfusion, bilirubin level decreased significantly (p |
| Databáze: | OpenAIRE |
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