Salmonella Typhimurium U32 peptidase, YdcP, promotes bacterial survival by conferring protection against in vitro and in vivo oxidative stress

Autor:	Dipasree Hajra, Abhilash Vijay Nair, Atish Roy Chowdhury, Soumyadeep Mukherjee, Ritika Chatterjee, Dipshikha Chakravortty
Rok vydání:	2022
Předmět:	Salmonella typhimurium Mice Inbred C57BL Mice Oxidative Stress Mice Inbred BALB C Infectious Diseases Bacteria Humans Animals NADPH Oxidases Hydrogen Peroxide Microbiology Peptide Hydrolases
Zdroj:	Microbial Pathogenesis. 173:105862
ISSN:	0882-4010
DOI:	10.1016/j.micpath.2022.105862
Popis:	YdcP, a U32 peptidase, is characterized as a putative collagenase with a role in several bacterial infections. However, its role in the pathogenesis of Salmonella Typhimurium remains elusive. Here, we investigated the role of U32 peptidase, YdcP, in the intracellular survival of S. Typhimurium (STM). Our study revealed a novel function of YdcP in protecting wild-type Salmonella from in vitro and in vivo oxidative stress. The ydcP knockout strain showed attenuated intracellular proliferation within the murine and human macrophages. Incubation of wild-type Salmonella with H
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4774bf37de67b4fa43d16a5f2d824bd3 https://doi.org/10.1016/j.micpath.2022.105862 Zobrazit plný text záznamu Full Text from ScienceDirect