Non-convulsive status epilepticus: COVID-19 or clozapine induced?
| Autor: | Laura Mantoan Ritter, Franz Brunnhuber, Shahrzad Hadavi, Elisaveta Sokolov |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Pneumonia Viral clinical neurophysiology Schizoaffective disorder Status epilepticus Electroencephalography Clinical neurophysiology epilepsy and seizures infection (neurology) Diagnosis Differential Betacoronavirus 03 medical and health sciences Status Epilepticus 0302 clinical medicine Humans Medicine 030212 general & internal medicine Intensive care medicine Clozapine Pandemics medicine.diagnostic_test SARS-CoV-2 business.industry COVID-19 General Medicine Middle Aged medicine.disease Psychotic Disorders Female medicine.symptom Differential diagnosis Coronavirus Infections business 030217 neurology & neurosurgery Findings That Shed New Light on the Possible Pathogenesis of a Disease or an Adverse Effect Antipsychotic Agents medicine.drug |
| Zdroj: | BMJ Case Reports |
| ISSN: | 1757-790X |
| DOI: | 10.1136/bcr-2020-239015 |
| Popis: | We present a case of non-convulsive status epilepticus in a 57-year-old woman with a schizoaffective disorder, without an antecedent seizure history, with two possible aetiologies including SARS-CoV-2 infection and clozapine uptitration. We discuss the presentation, investigations, differential diagnosis and management. In particular, we focus on the electroencephalogram (EEG) findings seen in this case and the electroclinical response to antiepileptic medication. We review the literature and discuss the relevance of this case to the SARS-CoV-2 global pandemic. We emphasise the importance of considering possible neurological manifestations of SARS-CoV-2 infection and highlight seizure disorder as one of the possible presentations. In addition, we discuss the possible effects of clozapine on the electroclinical presentation by way of possible seizure induction as well as discuss the possible EEG changes and we highlight that this needs to be kept in mind especially during rapid titration. |
| Databáze: | OpenAIRE |
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