Studies on the mechanism of inhibition of chemotactic tripeptide stimulated human neutrophil polymorphonuclear leucocyte superoxide production by chloroquine and hydroxychloroquine
| Autor: | W H Betts, J K French, Nigel P. Hurst, L. Gorjatschko |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Neutrophils
Immunology Tripeptide Pharmacology General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Rheumatology Superoxides Chloroquine Humans Immunology and Allergy Medicine Receptor Dose-Response Relationship Drug business.industry Superoxide hemic and immune systems Chemotaxis Hydroxychloroquine N-Formylmethionine leucyl-phenylalanine N-Formylmethionine Leucyl-Phenylalanine Chemotaxis Leukocyte chemistry Biochemistry Liberation lipids (amino acids peptides and proteins) business Research Article medicine.drug |
| Zdroj: | Annals of the Rheumatic Diseases. 46:750-756 |
| ISSN: | 0003-4967 |
| DOI: | 10.1136/ard.46.10.750 |
| Popis: | The effect of chloroquine and hydroxychloroquine on neutrophil superoxide release stimulated by the chemotactic tripeptide N-formyl-methionyl-leucyl-phenylalanine (FMLP) was examined. Both drugs caused time and dose dependent inhibition of superoxide release but had no effect on equilibrium binding of [3H]FMLP to its receptor. Preliminary experiments suggest that these drugs may exert their inhibitory effect on superoxide release by inhibiting the FMLP stimulated hydrolysis of phosphoinositides. |
| Databáze: | OpenAIRE |
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