Clofarabine Dosing in a Patient With Acute Myeloid Leukemia on Intermittent Hemodialysis: Case Report and Review of the Literature
| Autor: | David Frame, Lydia L. Benitez, Rajen Mody, Katherine N. Gharibian, Erika Mora |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Oncology Antimetabolites Antineoplastic medicine.medical_specialty medicine.medical_treatment Context (language use) Young Adult 03 medical and health sciences 0302 clinical medicine Renal Dialysis Adenine nucleotide Internal medicine medicine Humans Clofarabine Dosing Young adult Dialysis Adenine Nucleotides business.industry Myeloid leukemia Hematology Leukemia Myeloid Acute 030220 oncology & carcinogenesis Pediatrics Perinatology and Child Health Arabinonucleosides Hemodialysis business 030215 immunology medicine.drug |
| Zdroj: | Journal of Pediatric Hematology/Oncology. 39:481-484 |
| ISSN: | 1077-4114 |
| Popis: | Clofarabine containing chemotherapeutic regimens have demonstrated efficacy in the treatment of relapsed refractory acute myeloid leukemia. Nonetheless, there are limited data on the use of clofarabine in patients with renal failure. The present report describes the use of clofarabine in a patient with renal failure undergoing intermittent dialysis. We describe our rationale for dosing, clofarabine plasma levels obtained, and discuss our findings in the context of other available literature. Consistent with previous findings, intermittent hemodialysis was not found to be a reliable method of removing clofarabine in patients with renal insufficiency. |
| Databáze: | OpenAIRE |
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