Haemosiderin and tissue damage
| Autor: | John F. Gibson, Timothy J. Peters, Malcolm P. Weir |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Magnetic Resonance Spectroscopy
Free Radicals Iron Clinical Biochemistry chemistry.chemical_element Hemosiderin Biochemistry chemistry.chemical_compound Tissue damage medicine Humans Hemochromatosis biology Magnesium Spectrum Analysis Electron Spin Resonance Spectroscopy Lysosomal proteolysis Large aggregate Cell Biology General Medicine Metabolism Lipid Metabolism Phosphate medicine.disease Molecular Weight Ferritin chemistry Ferritins biology.protein Lysosomes |
| Zdroj: | Cell Biochemistry and Function. 2:186-194 |
| ISSN: | 1099-0844 0263-6484 |
| DOI: | 10.1002/cbf.290020402 |
| Popis: | High levels of haemosiderin occur in iron overload syndromes such as idiopathic haemochromatosis or secondary iron overload in thalassaemic patients; haemosiderin is the predominant iron-storage compound in such cases. It consists of a large aggregate of FeOOH cores, many of which have an incomplete shell of protein, and is probably derived from ferritin by lysosomal proteolysis. In addition, some chemical degradation of the ferritin cores appears to occur on conversion to haemosiderin. Other biochemical components are phosphate and magnesium, which may be adsorbed to the core surface, and perhaps certain lipids. Haemosiderin may have a central role, either directly or indirectly, in iron cytotoxicity and therefore the chemistry and biochemistry of this material warrants further study. |
| Databáze: | OpenAIRE |
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