Predicting the clinical efficacy and potential adverse effects of a humanized anticocaine monoclonal antibody
| Autor: | William J. Ball, Andrew B. Norman |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.drug_class
medicine.medical_treatment Immunology Endogeny Pharmacology Antibodies Monoclonal Humanized Monoclonal antibody Article Cocaine-Related Disorders Mice Cocaine Pharmacokinetics medicine Animals Humans Immunology and Allergy Clinical efficacy Anesthetics Local Adverse effect business.industry Immunogenicity Immunization Passive Brain Immunotherapy Disease Models Animal Oncology Pharmacodynamics business |
| Zdroj: | Immunotherapy. 4:335-343 |
| ISSN: | 1750-7448 1750-743X |
| Popis: | The effects of a humanized monoclonal antibody (mAb) having high affinity and specificity for cocaine in animal models are reviewed. The mAb reduced the concentration of cocaine in the brain of mice after intravenous injection of cocaine. In addition, the mAb increased the concentration of cocaine required to reinstate cocaine self-administration. These effects may predict clinical efficacy of a passive immunotherapy for reducing the probability of cocaine-induced relapse. However, in the presence of the mAb, once cocaine self-administration was reinstated, the consumption rate of cocaine was increased. This effect is hypothesized to result from a pharmacokinetic/pharmacodynamic interaction. A humanized mAb should minimize adverse events related to the immunogenicity of the mAb protein, and the specificity for cocaine should avoid adverse events related to interactions with physiologically relevant endogenous proteins. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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