Obesity in Pulmonary Arterial Hypertension. The Pulmonary Hypertension Association Registry
| Autor: | Jeff Min, Rui Feng, David Badesch, Erika Berman-Rosenzweig, Charles Burger, Murali Chakinala, Teresa De Marco, Jeremy Feldman, Anna Hemnes, Evelyn M. Horn, Matthew R. Lammi, Stephen Mathai, John W. McConnell, Kenneth Presberg, Jeffrey Robinson, Jeffrey Sager, Oksana Shlobin, Marc Simon, Thenappan Thenappan, Corey Ventetuolo, Nadine Al-Naamani, Roblee Allen, Sonja Bartolome, Raymond Benza, Todd Bull, Linda Cadaret, Michael Eggert, Jean Elwing, Jeffrey Fineman, Raymond Foley, H. James Ford, Robert Frantz, Russel Hirsch, James Grinnan, D. Dunbar Ivy, Steven Kawut, Jamie Kennedy, James Klinger, Peter Leary, Sula Mazimba, Gautam Ramani, Amresh Raina, James Runo, John Swisher, John Ryan, Nidhy Varghese, R. James White, Timothy Williamson, Delphine Yung, Roham Zamanian, Dianne Zwicke |
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| Rok vydání: | 2021 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty business.industry medicine.disease Obesity Pulmonary hypertension humanities 03 medical and health sciences 0302 clinical medicine 030228 respiratory system Quality of life Internal medicine Medicine 030212 general & internal medicine business Survival analysis Original Research |
| Zdroj: | Ann Am Thorac Soc |
| ISSN: | 2325-6621 2329-6933 |
| DOI: | 10.1513/annalsats.202006-612oc |
| Popis: | Rationale: Obesity is associated with pulmonary arterial hypertension (PAH), but its impact on outcomes such as health-related quality of life (HRQoL), hospitalizations, and survival is not well understood. Objectives: To assess the effect of obesity on HRQoL, hospitalizations, and survival in patients with PAH. Methods: We performed a cohort study of adults with PAH from the Pulmonary Hypertension Association Registry, a prospective multicenter registry. Multivariate linear mixed-effects regression was used to examine the relationship between weight categories and HRQoL using the Short Form-12 and emPHasis-10. We used multivariable negative binomial regression to estimate hospitalization incidence rate ratios (IRRs) and Cox regression to estimate hazard ratios (HRs) for transplant-free survival by weight status. Results: A total of 767 subjects were included (mean age of 57 years, 74% female, 33% overweight, and 40% with obesity), with median follow-up duration of 527 days. Overweight patients and patients with obesity had higher baseline emPHasis-10 scores (worse HRQoL), which persisted over time (P |
| Databáze: | OpenAIRE |
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