Characterization of tumor-associated antigen from human carcinoma of the uterine cervix
| Autor: | J. S. Nadkarni, Ram M. Rajpal, Jayshree J. Nadkarni, Srikrishna R. Damle, Mangesh N. Satam |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Pathology
medicine.medical_specialty Placenta Uterine Cervical Neoplasms Immune system Antigen Antigens Neoplasm Pregnancy Leukocytes Carcinoma medicine Homologous chromosome Animals Humans chemistry.chemical_classification Cervical cancer Immunity Cellular business.industry Obstetrics and Gynecology Alkaline Phosphatase medicine.disease In vitro Enzyme Oncology chemistry Cell Migration Inhibition Cancer research Alkaline phosphatase Female Rabbits business |
| Zdroj: | Gynecologic Oncology. 13:175-183 |
| ISSN: | 0090-8258 |
| DOI: | 10.1016/0090-8258(82)90025-7 |
| Popis: | In vitro demonstration of cell-mediated immune responses to tumor-associated antigen (TAA) was observed with autologous tumor extracts from patients with cervical cancer. Seventy-six percent of these patients exhibited an inhibitory effect with autologous antigens while 59% reacted with homologous antigens. A progressive rise in percentage inhibitory activity was associated with increasing stage of the disease. The physicochemical and immunochemical characterization of the TAA found on the membrane of cervical tumor cells suggested that it may be a lipid-protein complex containing an enzyme having immunological determinants such as those of term-placental alkaline phosphatase enzyme. |
| Databáze: | OpenAIRE |
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