Spontaneous carcinosarcoma originating from the renal pelvis ina rat
| Autor: | Toyohiko Aoki, Satoru Hosokawa, Kazuhiro Hayakawa, Akira Inomata |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
renal pelvis
0301 basic medicine Pathology medicine.medical_specialty Stromal cell carcinosarcoma Case Report Abdominal cavity Toxicology lung Pathology and Forensic Medicine 03 medical and health sciences Parenchyma Carcinosarcoma metastasis Medicine Urothelium spontaneous Kidney business.industry Anatomy respiratory system Hyperplasia medicine.disease 030104 developmental biology medicine.anatomical_structure business Renal pelvis |
| Zdroj: | Journal of Toxicologic Pathology |
| ISSN: | 1881-915X 0914-9198 |
| Popis: | Carcinosarcoma is a rare neoplasm composed of malignant epithelial and stromal elements, and, for rats, carcinosarcomas in the kidney have not been reported. In a long-term study to gather background data, we encountered a spontaneous carcinosarcoma originating from the renal pelvis with metastasis to the lung. At necropsy, a mass was observed in the abdominal cavity, and white nodules were scattered in lung lobes. Microscopically, there was polypoid hyperplasia of the urothelium accompanied by hyperplasia of spindle stromal cells in the pelvis. The intra-abdominal tumor was composed of epithelial and stromal elements; in the lung, the tumor cells invaded along alveoli/bronchi and occasionally invaded the parenchyma from the blood vessels. Immunohistochemical and electron microscopic examinations revealed that the epithelial element consisted of transitional epithelial cells and that the stromal element consisted of lipoblasts. The tumor was diagnosed as a carcinosarcoma originating from the renal pelvis, and this is the first report of a carcinosarcoma originating from the renal pelvis in a rat. |
| Databáze: | OpenAIRE |
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