The effect of simultaneous exposure to cigarette smoke and noise on distortion product otoacoustic emissions in rats
| Autor: | Mahdi Mohammadi, Ali Khavanin, Ramazan Mirzaei, Seyed Bagher Mortazavi, Mehdi Sadeghi Malvajerdi, Raheleh Hashemi Habybabady |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Distortion product Hearing loss Health Toxicology and Mutagenesis Otoacoustic Emissions Spontaneous Audiology Toxicology Random Allocation 03 medical and health sciences 0302 clinical medicine Cigarette smoking Risk Factors otorhinolaryngologic diseases Animals Medicine Cigarette smoke Rats Wistar Risk factor Hearing Loss 030223 otorhinolaryngology Smoke business.industry Public Health Environmental and Occupational Health Rats Noise Exposure chamber Tobacco Smoke Pollution medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Toxicology and Industrial Health. 35:349-357 |
| ISSN: | 1477-0393 0748-2337 |
| DOI: | 10.1177/0748233719839865 |
| Popis: | Cigarette smoking is a possible risk factor for hearing loss. However, the impact of simultaneous exposure to noise and smoke on hearing has remained controversial. This study investigated the combined effect of exposure to cigarette smoking and noise on hearing loss. Three groups of male Wistar rats (275 ± 25 g) were subjected to white noise (102 ± 0.5 dB), cigarette smoking (20 cigarettes), and both cigarette smoking and noise for 8 h and 10 days inside the exposure chamber. The control group was exposed to neither noise nor smoke. Distortion product otoacoustic emissions (DPOAE) were measured before any intervention, and it was repeated 1, 7, and 21 days after the last exposure. One-day postexposure to noise, cigarette smoking, and both cigarette smoking and noise, the mean of DPOAE amplitudes decreased significantly ( p < 0.05) between, respectively, 5.7–30.7, 1.5–7.5, and 5.2–32.6 dB within the frequency range of 4620–9960. Temporal DPOAE change in rats exposed to noise or both cigarette smoking and noise was not significantly different ( p > 0.05). DPOAE amplitudes returned to the baseline values in the group subjected to smoking 21 days postexposure. The most permanent change was observed in rats exposed to both cigarette smoking and noise. Accordingly, simultaneous subacute exposure to noise and cigarette smoking increases the effect of noise on permanent hearing loss. Therefore, smoking workers exposed to noise might be at a greater risk of developing hearing loss, and it is recommended that authorities in charge take note of this evidence. |
| Databáze: | OpenAIRE |
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