Retrospective study on the pattern of off-label use of misoprostol in Tabuk, Saudi Arabia
| Autor: | Mohammed Omar Alsharif, Mohammed Ghabbash Almalki, Mohannad Sahaw Alsaeed, Kousalya Prabahar, Nouf M Alharthi, Wael Saeed Alshehri |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Stomach disorder miscarriage lcsh:Analytical chemistry lcsh:RS1-441 Bioengineering induction of abortion Abortion Off-label use General Biochemistry Genetics and Molecular Biology Miscarriage lcsh:Pharmacy and materia medica Obstetrics and gynaecology medicine off-label use General Pharmacology Toxicology and Pharmaceutics Medical prescription Misoprostol misoprostol lcsh:QD71-142 business.industry medicine.disease Regimen postpartum hemorrhage Emergency medicine Original Article business medicine.drug |
| Zdroj: | Journal of Pharmacy and Bioallied Sciences, Vol 13, Iss 1, Pp 88-92 (2021) Journal of Pharmacy & Bioallied Sciences |
| ISSN: | 0975-7406 |
| Popis: | Introduction: Off-label drug use (OLDU) refers to the prescription of a currently available and marketed medication for a use that has never been approved by the Food and Drug Administration (FDA). Misoprostol is one of the drugs which is used off-label. This drug, authorized for the treatment or prevention of peptic ulcers and other stomach disorders, is commonly used off-label for inducing labor or intrauterine device insertion. This research focuses on identifying the percentage of morbidity and mortality by off-label use of misoprostol; classifying the most common off-label misoprostol use in Tabuk hospitals; and determining the availability of policy and procedures behind prescribing the off-label misoprostol. Materials and Methods: Retrospective observational study was carried out. Data were collected from patients’ files for those admitted to the maternity wards in Tabuk Hospitals from March 2019 until September 2019. Results: Approximately 53% of cases were diagnosed with missed abortion. The mean time for abortion after administering misoprostol was 20.7 ± 28.2h. About 76% of women had an indication of bleeding. Guidelines were not followed with respect to dosage regimen. The mean of hospital stay was 3 days. There were no significant complications associated with the administration of misoprostol. Conclusion: There is no policy and procedure available in the hospital regarding off-label use of misoprostol. Moreover, physicians have low adherence to the guideline in terms of dosage, interval, and route of administration for each indication in obstetrics and gynecology. |
| Databáze: | OpenAIRE |
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