Association of migraine and ESR1 G325C polymorphism
| Autor: | Jesus Castillo, Amalia Cayón, Felix Gonzalez, Yolanda Bravo, Julio Pascual, Natalia Valle, Pablo Sánchez-Velasco, Ana Alonso-Arranz, Carlos Ruı́z de Alegrı́a, Francisco Leyva-Cobián, Agustín Oterino, Pedro Muñoz |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Genotype Migraine Disorders Population Central nervous system disease Sex Factors Gene Frequency Polymorphism (computer science) Internal medicine medicine Humans Genetic Predisposition to Disease Allele education education.field_of_study Chi-Square Distribution Polymorphism Genetic business.industry General Neuroscience Estrogen Receptor alpha Middle Aged medicine.disease Migraine with aura Confidence interval body regions Endocrinology Migraine Spain Female medicine.symptom business |
| Zdroj: | Neuroreport. 17(1) |
| ISSN: | 0959-4965 |
| Popis: | Migraine is a genetically complex disorder in which sexual hormones influence the phenotype. ESR1 G594A polymorphism has been associated with migraine in Australians. We performed a case-control study with G594A and G325C polymorphisms to determine whether ESR1 is associated with migraine in our population. An association between G594A and migraine could not be demonstrated here. By contrast, we observed that the C325 allele conferred a 1.6 (95% confidence interval=1.1-2.4) higher risk for suffering from migraine in women than the G allele. Women carrying the C352C genotype were over 3 times more likely to suffer from migraine than those carrying the G325G genotype. Therefore, we conclude that ESR1 G325C polymorphism is associated with migraine in our population. |
| Databáze: | OpenAIRE |
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