SAT-1 -1415T/C polymorphism and susceptibility to schizophrenia
| Autor: | Jerónimo Saiz-Ruiz, M. Mercedes Perez-Rodriguez, Enrique Baca-García, Carlos Riaza Bermudo-Soriano, Concepción Vaquero-Lorenzo, José Fernández-Piqueras, Montserrat Diaz-Hernandez |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Risk medicine.medical_specialty Psychosis Genotype Single-nucleotide polymorphism Biology Polymorphism Single Nucleotide chemistry.chemical_compound Gene Frequency Acetyltransferases Internal medicine medicine SNP Humans Allele Allele frequency Biological Psychiatry Pharmacology Genetics Psychiatric Status Rating Scales Reverse Transcriptase Polymerase Chain Reaction Case-control study medicine.disease Spermidine Endocrinology chemistry Psychotic Disorders Spain Case-Control Studies Schizophrenia Female |
| Zdroj: | Progress in neuro-psychopharmacologybiological psychiatry. 33(2) |
| ISSN: | 0278-5846 |
| Popis: | Patients suffering from psychosis show increased blood and fibroblast total polyamine levels. Spermidine/spermine N1-acetyltransferase (SSAT-1) and its coding gene (SAT-1) are the main factors regulating polyamine catabolism. The aim of the present study was to examine the association between the SAT-1 -1415T/C single nucleotide polymorphism (SNP) and schizophrenia. A case-control design was used in order to compare the genotypes for the SNP between schizophrenia patients (n=180, 83 females and 97 males), other non-psychotic psychiatric patients (n=413, 256 females and 157 males), and healthy controls (n=251, 101 females and 150 males). No significant differences in the distribution of the genotypes of the SAT-1 -1415T/C SNP were found groups among groups. We failed to demonstrate a significant association between the SAT-1 -1415T/C SNP and schizophrenia, but a mild association between allele C and psychopathology was found in the female group. |
| Databáze: | OpenAIRE |
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