Faecal shedding and intestinal colonization of Salmonella enterica in in-bred chickens: the effect of host-genetic background
| Autor: | Nat Bumstead, Kerrie L. Marston, Paul A. Barrow, M.A. Lovell, Paul Wigley |
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| Rok vydání: | 2004 |
| Předmět: |
Serotype
Salmonella Time Factors Epidemiology Antibodies Heterophile Biology Gut flora medicine.disease_cause Microbiology Feces Leukocyte Count Cloaca In vivo medicine Animals Inbreeding Serotyping Cecum Poultry Diseases Salmonella Infections Animal Inoculation Age Factors Salmonella enterica biology.organism_classification Antibodies Bacterial Enterobacteriaceae Immunity Innate Immunoglobulin A Disease Models Animal Infectious Diseases Immunoglobulin G Chickens Bacteria Research Article |
| Zdroj: | Epidemiology and Infection. 132:117-126 |
| ISSN: | 1469-4409 0950-2688 |
| DOI: | 10.1017/s0950268803001274 |
| Popis: | Considerable and reproducible differences were observed in the amount and duration of faecal excretion when in-bred lines of chickens were infected orally with S. enterica serovar Typhimurium at 6 weeks of age after being given a gut flora preparation when newly hatched. Similar but less pronounced results were observed with S. Enteritidis or S. Infantis. Differences in the viable numbers of the inoculated bacteria in caecal contents were detectable within 24 h of inoculation. No major differences were seen in Salmonella-specific serum IgA or IgG titres. Small differences were seen in the numbers of circulating heterophilic cells. Caecal contents taken from the more resistant lines immediately prior to challenge appeared to be no more inhibitory for Salmonella in vivo than contents taken from susceptible lines. The more resistant lines showed a slightly higher rate of intestinal flow, as indicated by the rate of production of faecal droppings, although there was no difference in the rate of emptying of the caeca. In an F1 generation resistance was dominant and not sex-linked. There was no MHC linkage or any association with SAL1, the gene implicated in resistance to systemic salmonellosis in chickens, or NRAMP1. |
| Databáze: | OpenAIRE |
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