The generation of granule cells during the development and evolution of the cerebellum
| Autor: | Cecilia B. Moens, Emily Capaldo, Angelo Iulianella, Richard J. T. Wingate |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cerebellum Cell type Cell Differentiation Neocortex Sensory system Hindbrain Biology Granule cell Rhombencephalon 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure nervous system Anamniotes Cerebellar cortex medicine Animals Humans Rhombic lip Neuroscience 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Developmental Dynamics. 248:506-513 |
| ISSN: | 1097-0177 1058-8388 |
| Popis: | The cerebellum coordinates vestibular input into the hindbrain to control balance and movement, and its anatomical complexity is increasingly viewed as a high-throughput processing center for sensory and cognitive functions. Cerebellum development however is relatively simple, and arises from a specialized structure in the anterior hindbrain called the rhombic lip, which along with the ventricular zone of the rostral-most dorsal hindbrain region, give rise to the distinct cell types that constitute the cerebellum. Granule cells, being the most numerous cell types, arise from the rhombic lip and form a dense and distinct layer of the cerebellar cortex. In this short review, we describe the various strategies used by amniotes and anamniotes to generate and diversify granule cell types during cerebellar development. |
| Databáze: | OpenAIRE |
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