USP28 contributes to the proliferation and metastasis of gastric cancer
| Autor: | Hong-Min Liu, Ting Zhang, Yi-Chao Zheng, Li-Juan Zhao, Xue-Jian Feng, Jin-Lian Ma, Ying-Jun Liu, Ying Liu, Jiao Chang, Feng-Zhi Suo |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Bladder cancer DNA repair business.industry Colorectal cancer digestive oral and skin physiology Cancer Cell Biology medicine.disease Biochemistry digestive system diseases Metastasis 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Immune system Apoptosis 030220 oncology & carcinogenesis Cancer cell medicine Cancer research business Molecular Biology |
| Zdroj: | Journal of Cellular Biochemistry. 120:7657-7666 |
| ISSN: | 1097-4644 0730-2312 |
| DOI: | 10.1002/jcb.28040 |
| Popis: | USP28, a member of the deubiquitinating enzymes family, plays a vital role in the physiological process of cell proliferation, differentiation and apoptosis, DNA repair, immune response, and stress response. USP28 has been reported to be overexpressed in bladder cancer, colon cancer, breast carcinomas, and so on. Nevertheless, the role of USP28 in gastric cancer has not yet been investigated. In our study, we examined the USP28 expression in 87 paired samples of gastric cancer and normal gastric tissues. We found that USP28 was overexpressed in gastric cancer compared with normal gastric tissues (P < 0.01), and its overexpression was related to the degree of differentiation and metastases. Inhibiting USP28 expression in vitro suppressed the proliferation and invasion of gastric cancer cells by downregulating lysine specific demethylase 1. On the basis of our data, it can be concluded that USP28 may be a novel therapeutic target for gastric cancer. |
| Databáze: | OpenAIRE |
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