Growth differentiation factor-9 is required during early ovarian folliculogenesis
| Autor: | N Lu, T R Kumar, David F. Albertini, Martin M. Matzuk, Katsuhiko Nishimori, Dong J |
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| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_specialty
Growth Differentiation Factor 9 Biology Growth differentiation factor-9 Cell Line Mice FIGLA Ovarian Follicle Primary follicle stage Internal medicine medicine Animals Ovarian follicle Growth Substances Multidisciplinary Bone morphogenetic protein 15 Ovary Cell Differentiation Oocyte Cell biology Mice Inbred C57BL Endocrinology medicine.anatomical_structure Gene Targeting embryonic structures Follicular Cyst Intercellular Signaling Peptides and Proteins Female Folliculogenesis Oocyte differentiation Bone Morphogenetic Protein 15 Infertility Female Gene Deletion |
| Zdroj: | Nature. 383:531-535 |
| ISSN: | 1476-4687 0028-0836 |
| DOI: | 10.1038/383531a0 |
| Popis: | Growth factors synthesized by ovarian somatic cells directly affect oocyte growth and function, but it is unclear whether oocyte-secreted factors play a reciprocal role in modulating somatic cell functions in vivo. During the functional analysis of members of the transforming growth factor-beta superfamily in mouse development, we have uncovered a new family member, growth differentiation factor-9 (GDF-9), which is required for ovarian folliculogenesis. GDF-9 messenger RNA is synthesized only in the oocyte from the primary one-layer follicle stage until after ovulation. Here we analyse ovaries from GDF-9-deficient female mice and demonstrate that primordial and primary one-layer follicles can be formed, but there is a block in follicular development beyond the primary one-layer follicle stage which leads to complete infertility. Oocyte growth and zona pellucida formation proceed normally, but other aspects of oocyte differentiation are compromised. Thus, GDF-9 is the first oocyte-derived growth factor required for somatic cell function in vivo. |
| Databáze: | OpenAIRE |
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