Thrombospondin 1 Triggers Osteosarcoma Cell Metastasis and Tumor Angiogenesis
| Autor: | Huan Ye Zhu, Xing Lin Wu, Bo Li, Yue Kui Jian |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
CD36 Antigens Cancer Research endocrine system Lung Neoplasms Angiogenesis Bone Neoplasms Article Metastasis Neovascularization Thrombospondin 1 03 medical and health sciences Mice 0302 clinical medicine Vasculostatin Cell Line Tumor Medicine TSP-1 Animals Humans Tube formation Thrombospondin Osteosarcoma Mice Inbred BALB C Neovascularization Pathologic business.industry General Medicine medicine.disease 030104 developmental biology Oncology 030220 oncology & carcinogenesis Cancer research medicine.symptom business CD36 |
| Zdroj: | Oncology Research |
| ISSN: | 1555-3906 0965-0407 |
| Popis: | Osteosarcomas, especially those with metastatic or unresectable disease, have limited treatment options. The antitumor effects of pharmacologic inhibitors of angiogenesis in osteosarcomas are hampered in patients by the rapid development of tumor resistance, notably through increased invasiveness and accelerated metastasis. Here we demonstrated that thrombospondin 1 (TSP-1) is a potent inhibitor of the growth and metastasis of the osteosarcoma cell line MG-63. Moreover, we demonstrate that upregulation of TSP-1 facilitated expression of vasculostatin in MG-63 cells. In angiogenesis assays, overexpression of TSP-1 inhibited MG-63 cells and induced tube formation of human umbilical vein endothelial cells (HUVECs) in a CD36-dependent fashion. Finally, in xenografted tumors, we observed that TSP-1 overexpression inhibited angiogenesis and tumor growth. These results provided strong evidence for an important role of the TSP-1/CD36/vasculostatin signaling axis in mediating the antiangiogenic activity of osteosarcoma. |
| Databáze: | OpenAIRE |
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