Maternal Thyroid Function at 11–13 Weeks of Gestation and Spontaneous Preterm Delivery
| Autor: | Ghalia Ashoor, Nerea Maiz, Kypros H. Nicolaides, Michael Rotas, Firas Jawdat |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty endocrine system diseases Thyroid Gland Thyrotropin Iodide Peroxidase Thyroglobulin Antibodies Pregnancy medicine Humans Retrospective Studies biology Obstetrics business.industry Multiple of the median Obstetrics and Gynecology Gestational age Retrospective cohort study medicine.disease Pregnancy Trimester First Thyroxine biology.protein Premature Birth Gestation Female Thyroid function Antibody business Hormone |
| Zdroj: | Obstetrics & Gynecology. 117:293-298 |
| ISSN: | 0029-7844 |
| DOI: | 10.1097/aog.0b013e318205152c |
| Popis: | OBJECTIVE To estimate the possible association between spontaneous early preterm delivery and maternal thyroid dysfunction in early pregnancy. METHODS Maternal serum concentrations of thyroid-stimulating hormone (TSH), free thyroxine, antithyroperoxidase, and antithyroglobulin antibodies at 11-13 weeks of gestation were compared in 102 singleton pregnancies, resulting in spontaneous delivery before 34 weeks and 4,318 normal pregnancies delivering after this gestation. RESULTS In the preterm delivery group, compared with the normal outcome group, there was no significant difference in antithyroid antibody positivity (16.7% compared with 16.8%). In the antithyroid antibody-negative pregnancies in the preterm delivery group, compared with the normal outcome group, the median free thyroxine multiple of the median was reduced (0.94 compared with 0.99 multiple of the median, P |
| Databáze: | OpenAIRE |
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