Investigation of resistin 420 and 62 gene polymorphism in patients with endometrial cancer
| Autor: | Bedia Cakmakoglu, Halil Saygili, Onay Yalcin, Ercan Bastu, Bahar Yuksel Ozgor, Cem Iyibozkurt, Sinan Berkman |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
medicine.medical_specialty Single-nucleotide polymorphism Gastroenterology lcsh:Gynecology and obstetrics Polymorphism Single Nucleotide 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Internal medicine medicine SNP Humans In patient Resistin Prospective Studies Gene lcsh:RG1-991 Alleles Neoplasm Staging 030219 obstetrics & reproductive medicine business.industry Endometrial cancer Obstetrics and Gynecology Middle Aged medicine.disease Endometrial Neoplasms Case-Control Studies Female Gene polymorphism business Carcinoma Endometrioid |
| Zdroj: | Taiwanese Journal of Obstetrics & Gynecology, Vol 58, Iss 1, Pp 164-167 (2019) |
| ISSN: | 1875-6263 |
| Popis: | Objective: We aimed to assess resistin gene polymorphisms, namely 420C > G and 62G > A and their effect on the risk of endometrial cancer (EC). Materials and methods: Between January 2012 and January 2015, of the total of 183 patients diagnosed with EC, 94 patients were enrolled into the study. Patients with diabetes mellitus, hypertension and history of any other cancer were excluded. To identify the importance of nucleotide polymorphism including 420C > G and 62G > A in the resistin gene, 94 healthy volunteers were included as the control group. Results: Among the Resistin 420 gene polymorphism profiles, 420 GC (47.9%) was the most common gene polymorphism in the EC group. Also, the polymorphism of 420 CC (57.7%, p: 0.002) lead the list in the control group followed by the 420GC (37.5%) polymorphism. Resistin 62 gene polymorphism analysis demonstrated that the 62GC polymorphism was significantly more common in the EC group (p C and 62G > A gene polymorphisms play a role in EC development. Keywords: Endometrial cancer, Gene polymorphism, Resistin, SNP |
| Databáze: | OpenAIRE |
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