Fluctuations of Unbound Whole Blood Polyamine Levels during the Menstrual Cycle
| Autor: | David W. Lundgren, Jeanne Hankins, Philip M. Farrell, Lawrence F. Cohen |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Adult
Male medicine.medical_specialty Spermidine media_common.quotation_subject Population Endometrium General Biochemistry Genetics and Molecular Biology Internal medicine medicine Humans Castration education Menstrual cycle Testosterone media_common Whole blood education.field_of_study business.industry fungi Menstruation Contraceptives Oral Combined Endocrinology medicine.anatomical_structure Ovariectomized rat Female Spermine Luteinizing hormone business Hormone |
| Zdroj: | Experimental Biology and Medicine. 152:81-85 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-152-39333 |
| Popis: | The polyamines putrescine spermadine (SPD) and spermine (SPM) appear to be ubiquitous in animal tissues. Several hormones including luteinizing hormone estradiol and testosterone affect polyamine biosynthesis. Polyamines can substitute for hormones in some biologic responses. Various neoplastic states are accompanied by increased levels of tissue and circulating polyamines and successful treatment has led to their reduction. Male but not female homo- and heterozygotes for cystic fibrosis have had a specifically increased Spd/Spm ratio in unhydrolyzed whole blood. In this study unhydrolyzed whole blood was examined for Spd and Spm concentrations and ratios in 4 normal women 3 normal males and 1 ovariectomized woman over a 4-week period. Of the women 1 began taking an oral contraceptive containing 1 mg ethynodiol diacetate and 50 mcg ethinyl estradiol 30 days after the study and her Spd/Spm concentrations and ratios were studied for 22 additional days. The ovariectomized female 6 months earlier had had a total abdominal hysterectomy and ovariectomy for adenocarcinoma of the endometrium. Techniques used in extracting polyamines are given. Polyamines in this study refer to free as opposed to total polyamines. Male concentrations showed more variations than did the ratios of Spd/Spm. Female Spd/Spm ratios showed marked fluctuations (p less than .029). Female ratios appeared to rise after the last day of the menses and then to fall. Their concentrations showed a high degree of fluctuation. In the female receiving oral contraceptives the ratio pattern showed very little variation (p less than .62) and was similar to that of the males. For the ovariectomized woman the Spd/Spm ratio showed very little fluctuation and was similar to that of the males. Results suggest that a sex-related hormone(s) influences concentrations and ratios of Spd and Spm. It is suggested that particularly in males abnormal polyamines in whole blood may be useful in the diagnosis or in following the clinical course of cancer or of cystic fibrosis. In females findings must be correlated with the menstrual cycles. |
| Databáze: | OpenAIRE |
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