Significant dominance of fibrinogen over immunoglobulins, C-reactive protein, cholesterol and triglycerides in maintaining increased red blood cell adhesiveness/aggregation in the peripheral venous blood: a model in hypercholesterolaemic patients
| Autor: | M. Hirsch, Vered Schechner, Shlomo Berliner, Itzhak Shapira, David Zeltser, T. Hershcovici, Meirav Rozenblat, D. Comaneshter, K. Lachmi, Y. Beigel, J. Orlin |
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| Rok vydání: | 2003 |
| Předmět: |
Erythrocyte Aggregation
medicine.medical_specialty Erythrocytes Clinical Biochemistry Hypercholesterolemia Immunoglobulins Biology Fibrinogen Biochemistry Erythrocyte aggregation chemistry.chemical_compound Internal medicine medicine Cell Adhesion Image Processing Computer-Assisted Humans Triglycerides Red Cell Triglyceride Cholesterol General Medicine Venous blood Lipoproteins LDL Red blood cell medicine.anatomical_structure Endocrinology C-Reactive Protein Logistic Models chemistry LDL apheresis Immunology Blood Component Removal medicine.drug |
| Zdroj: | European journal of clinical investigation. 33(11) |
| ISSN: | 0014-2972 |
| Popis: | Background It is not clear what is the relative importance of fibrinogen, immunoglobulins, highly sensitive C-reactive protein (hs-CRP), cholesterol and triglyceride concentrations on the appearance of aggregated red blood cells in the peripheral blood. Design Six hypercholesterolaemic patients undergoing regular LDL apheresis that were examined repeatedly before and following the procedure. Results We determined the degree of erythrocyte adhesiveness/aggregation in relation to the concentration of the above-mentioned macromolecules in 80 samples. In a linear logistic regression the respective R2 values for fibrinogen, total cholesterol, triglycerides, hs-CRP, IgG, IgM and IgA were 0·45 (P |
| Databáze: | OpenAIRE |
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